Pair Name	Nimbolide, Docetaxel
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Activity	NFKB1	hsa4790
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	LNCaP	Prostate carcinoma	Homo sapiens (Human)	CVCL_0395
	PC-3	Prostate carcinoma	Homo sapiens (Human)	CVCL_0035
	PC-3 D12	Prostate carcinoma	Homo sapiens (Human)	CVCL_4Y40
In Vivo Model	8-week-old male SCID mice were orthotopically implanted with LNCaP-Luc or PC-3-Luc cells to induce tumors.
Result	The combination of NL and DTX significantly reduced the DNA binding ability of NF-κB in both cell types. NL significantly enhanced the antitumor effect of DTX and reduced metastases in orthotopic models of prostate cancer. NL abolishes DTX-induced-NF-κB activation to counteract cell proliferation, tumor growth, and metastasis in the prostate cancer models.